H?gh d???? can r??ult ?n v?r? h?gh bl??d ?r???ur? ?r b?d? t?m??r?tur?. Eff??t? b?g?n inside seconds to minutes of u?? and l??t b?tw??n f?v? and n?n?t? m?nut??. R????t?d ?????n? use ??n ?r?du?? ?dd??t??n ?nd other ?dv?r?? h??lth consequences. In 2014, ????rd?ng to th? NSDUH, ?b?ut 913,000 Am?r???n